K+ voltage-gated channel subfamily E member 2; minK-related peptide 1; minimum K+ channel-related peptide 1; K+ channel subunit beta MiRP1 (KCNE2)

Function

• ancillary protein that assembles as a beta subunit with a voltage-gated K+ channel complex of pore-forming alpha subunits
• modulates the gating kinetics & enhances stability of the channel complex
• associated with KCNH2/HERG
• proposed to form the rapidly activating component of the delayed rectifying K+ current in heart (IKr)
• may associate with KCNQ2 &/or KCNQ3 & modulate the native M-type current
• may associate with KCNQ1/KVLTQ1 & elicit a voltage-independent current
• may associate with HCN1 & HCN2 & increase K+ current
• associates with KCNH2/ERG1
• may associate with KCNQ1/KVLQT1, KCNQ2 & KCNQ3
• associates with HCN1 & probably HCN2 (putative)

Structure

belongs to the K+ channel KCNE family

Compartment

• membrane; single-pass type 1 membrane protein

Expression

• highly expressed in brain, heart, skeletal muscle, pancreas, placenta, kidney, colon & thymus
• low but significant expression in liver, ovary, testis, prostate, small intestine & leukocytes
• very low expression, nearly undetectable, in lung & spleen

Pathology

• defects in KCNE2 are the cause of
  • long QT syndrome type 6
  • atrial fibrillation familial type 4

More general terms

• glycoprotein
• K+ channel subfamily E
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9992
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9992
• OMIM: https://mirror.omim.org/entry/603796
• OMIM: https://mirror.omim.org/entry/611493
• UniProt: http://www.uniprot.org/uniprot/Q9Y6J6.html