K+ voltage-gated channel subfamily KQT member 3; KQT-like 3; K+ channel subunit alpha KvLQT3; voltage-gated K+ channel subunit Kv7.3 (KCNQ3)

Function

• role in regulation of neuronal excitability (putative)
• associates with KCNQ2 or KCNQ5 to form a K+ channel with essentially identical properties to the channel underlying the native M-current, a slowly activating & deactivating K+ conductance which plays a role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs
• heteromultimer with KCNQ2 or KCNQ5
• may associate with KCNE2

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position (putative)
• belongs to the K+ channel family, KQT (TC 1.A.1.15) subfamily, Kv7.3/KCNQ3 sub-subfamily

Compartment

membrane

Expression

predominantly expressed in brain

Pathology

• defects in KCNQ3 are the cause of benign familial neonatal epilepsy type 2

More general terms

• transmembrane 6 protein
• K+ channel subfamily KQT
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3786
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3786
• OMIM: https://mirror.omim.org/entry/121201
• OMIM: https://mirror.omim.org/entry/602232
• UniProt: http://www.uniprot.org/uniprot/O43525.html