K+ voltage-gated channel subfamily KQT member 5; KQT-like 5; K+ channel subunit alpha KvLQT5; voltage-gated K+ channel subunit Kv7.5 (KCNQ5)

Function

• role in regulation of neuronal excitability (putative)
• associates with KCNQ3 to form a K+ channel which contributes to M-type current, a slowly activating & deactivating K+ conductance which plays a role in determining the subthreshold electrical excitability of neurons
• may contribute, with other K+ channels, to the molecular diversity of an heterogeneous population of M-channels
• insensitive to tetraethylammonium, but inhibited by barium, linopirdine & XE991
• activated by niflumic acid & the anticonvulsant retigabine
• muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with muscarinic M1 receptors
• heteromultimer with KCNQ3

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position (putative)
• belongs to the K+ channel family, KQT (TC 1.A.1.15) subfamily, Kv7.5/KCNQ5 sub-subfamily

Compartment

membrane

Alternative splicing

named isoforms=4

Expression

• strongly expressed in brain & skeletal muscle
• in brain
  • expressed in cerebral cortex, occipital pole, frontal lobe & temporal lobe
  • lower levels of expression in hippocampus & putamen
  • low to undetectable expession in medulla oblongata, cerebellum & thalamus

More general terms

• transmembrane 6 protein
• K+ channel subfamily KQT

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56479
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56479
• OMIM: https://mirror.omim.org/entry/607357
• UniProt: http://www.uniprot.org/uniprot/Q9NR82.html