ezogabine (Potiga, retigabine)

From Aaushi
Jump to navigation Jump to search

Introduction

FDA approved June 2011

Indications

Dosage

  • start: 100 mg TID for 1 week
  • titrate at weekly intervals; increase by <= 150 mg/day
  • maintenance: 200-400 mg TID*
  • taper over 3 weeks when discontinuing[7]

* 400 mg TID of limited benefit with increased incidence of adverse effects relative to 300 mg TID[7]

Monitor

Adverse effects

Laboratory

Mechanism of action

More general terms

References

  1. FDA NEWS RELEASE: June 13, 2011 FDA approves Potiga to treat seizures in adults http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm258834.htm
  2. French JA et al. on behalf of the RESTORE 1/Study 301 Investigators. Randomized, double-blind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy. Neurology 2011 Mar 30 http://www.neurology.org/content/76/18/1555
  3. 3.0 3.1 3.2 FDA MedWatch, April 26, 2013 Potiga (Ezogabine): Drug Safety Communication - Linked To Retinal Abnormalities And Blue Skin Discoloration. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm349847.htm
  4. 4.0 4.1 FDA Drug Safety Communication: FDA approves label changes for anti-seizure drug Potiga (ezogabine) describing risk of retinal abnormalities, potential vision loss, and skin discoloration. October 31, 2013 http://www.fda.gov/Drugs/DrugSafety/ucm372774.htm
  5. 5.0 5.1 FDA Drug Safety Communication. June 16, 2015 Potiga (ezogabine): Drug Safety Communication - FDA Determines 2013 Labeling Adequate to Manage Risks of Retinal Abnormalities, Potential Vision Loss, and Skin Discoloration. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm451181.htm
  6. 6.0 6.1 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
  7. 7.0 7.1 7.2 Ezogabin (Potiga) tablets prescribing information https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Potiga/pdf/POTIGA-PI-MG.PDF

Database