macrolide (macrolide antibiotic)

From Aaushi
Jump to navigation Jump to search

Structure

  • a group of macrocyclic compounds formed by chain extension of multiple proprionates & cyclized into a 12-16 membered lactone
  • often glycosylated

Indications

Contraindications

Adverse effects

Mechanism of action

* macrolide may improve clinical outcome despite antibiotic resistance[3]

More general terms

More specific terms

References

  1. NLM MeSH Browser http://www.nlm.nih.gov/mesh/meshhome.html
  2. Kunisaki KM and Niewoehner DE Antibiotic prophylaxis for chronic obstructive pulmonary disease: resurrecting an old idea. Am J Respir Crit Care Med. 2008 Dec 1;178(11):1098-9 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19023036
  3. 3.0 3.1 3.2 Ampel NM Should Macrolides Be Used for Community-Acquired Pneumonia? NEJM Journal Watch. June 16, 2015 Massachusetts Medical Society (subscription needed) http://www.jwatch.org
    Cilloniz C et al. The effect of macrolide resistance on the presentation and outcome of patients hospitalized for Streptococcus pneumoniae pneumonia. Am J Respir Crit Care Med 2015 Jun 1; 191:1265. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25807239
    Niederman MS. Macrolide-resistant pneumococcus in community-acquired pneumonia: Is there still a role for macrolide therapy? Am J Respir Crit Care Med 2015 Jun 1; 191:1216. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26029831
  4. 4.0 4.1 Berard A et al Use of macrolides during pregnancy and the risk of birth defects: a population-based study. Pharmacoepidemiology and Drug Safety. Oct 29, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26513406 <Internet> http://onlinelibrary.wiley.com/doi/10.1002/pds.3900/abstract;jsessionid=D48B754D181DE5E6CC5507D7E5D0E6FC.f03t01
  5. 5.0 5.1 Fan H, Gilbert R, O'Callaghan F, Li L Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. BMJ 2020;368:m331 PMID: https://www.ncbi.nlm.nih.gov/pubmed/32075790 Free Article https://www.bmj.com/content/368/bmj.m331
  6. 6.0 6.1 Vanoverschelde A, Oosterloo BC, Ly NF et al. Macrolide-associated ototoxicity: A cross-sectional and longitudinal study to assess the association of macrolide use with tinnitus and hearing loss. J Antimicrob Chemother 2021 Jul 27; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34312676 https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkab232/6328751