epothilone

Introduction

A group of 16-member macrolides.

Includes:

• epothilone A
• epothilone B
• epothilone C
• epothilone D

Mechanism of action

• microtubule stabilization
  • interaction with microtubules differs from taxanes
• promotes apoptosis

Synthethic & derived from myxobacterium Sorangium cellosum now renamed to Polyangium (Myxococaccales)

More general terms

• epoxide
• thiazole
• macrolide (macrolide antibiotic)
• antineoplastic agent (chemotherapeutic agent)

More specific terms

• epothilone A
• epothilone B
• epothilone C
• epothilone D