fluvastatin (Lescol)

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Introduction

Tradename: Lescol.

Indications

Contraindications

pregnancy category = x

safety in lactation = -

Dosage

Tabs: 20 & 40 mg; Lescol XL 80 mg (sustained release).

Pharmacokinetics

elimination via liver

protein binding = 98 %

1/2life = 1.2 hours

Monitor

(see HMG CoA reductase inhibitor)

Adverse effects

Drug interactions

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
  3. Geriatric Dosage Handbook, 6th edition, Selma et al eds, Lexi-Comp, Cleveland, 2001
  4. 4.0 4.1 Do All Statins Need to be Taken in the Evening? Prescriber's Letter 10(12):70 2003 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=191206&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. 5.0 5.1 5.2 Deprecated Reference
  6. 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Wiggins BS, Saseen JJ, Page RL 2nd et al Recommendations for Management of Clinically Significant Drug-Drug Interactions With Statins and Select Agents Used in Patients With Cardiovascular Disease. A Scientific Statement From the American Heart Association. Circulation. 2016;134:00-00 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27754879 <Internet> http://circ.ahajournals.org/content/circulationaha/early/2016/10/17/CIR.0000000000000456.full.pdf
  7. Department of Veterans Affairs, VA National Formulary

Database