cytochrome P450 2C8; cytochrome P450 2C2, cytochrome P450 form 1; cytochrome P450 MP-12/MP-20; S-mephenytoin-4-hydroxylase (CYP2C8)

Function

• NADPH-dependent electron transport pathway
• oxidizes a variety of structurally unrelated compounds
  • steroids
  • fatty acids
    • in the epoxidation of arachidonic acid, generates only 14,15- & 11,12-cis-epoxyeicosatrienoic acids
  • xenobiotics
• inducers
  • carbamazepine
  • nilotinib
  • phenobarbital
  • rifabutin
  • rifampicin
  • rifampin
• inhibitors
  • atazanavir
  • anastrozole
  • gemfibrozil
  • lapatinib
  • montelukast
  • nicardipine
  • nilotinib
  • pazopanib
  • quercetin
  • sorafenib
  • sulfinpyrazone
  • trimethoprim
  • vilazodone
• substrates
  • amiodarone
  • benzphetamine
  • carbamazepine
  • docetaxel
  • fluvastatin
  • isotretinoin
  • lapatinib
  • methadone
  • paclitaxel
  • phenytoin
  • pioglitazone
  • repaglinide
  • retinoic acid
  • retinol
  • rosiglitazone
  • tolbutamide
  • tretinoin
  • verapamil
  • warfarin
  • zopiclone

Compartment

membrane-bound, endoplasmic reticulum

Alternative splicing

• occurs, but the shorter forms are believed to be non-functional

Expression

induced by phenobarbital (see inducers)

Laboratory

• CYP2C8 gene mutation

More general terms

• cytochrome P450 2C (CYP2C)

Database

• UniProt: http://www.uniprot.org/uniprot/P10632.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1558
• OMIM: https://mirror.omim.org/entry/601129
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1558