vilazodone (Viibryd)

Indications

• major depression (FDA-approved Jan 2011)

Contraindications

• vilazodone & MAO inhibitors should not be used together or within 14 days of each other

Pregnancy category: C

Dosage

• start 10 mg QD with food
• after 7 days, increase to 20 mg QD
• after 14 days, increase to 40 mg QD, dose with food
• taper if discontinuing

Tabs: 10, 20, 40 mg

Pharmacokinetics

• metabolized by CYP3A4
• inhibits CYP2C8
• protein-binding 96-99%

Adverse effects

• diarrhea (28%), nausea (23%), vomiting (5%)
• dizziness (9%)
• xerostomia (6%)
• xerophthalmia (5%)
• insomnia
• may cause new or worsening cataracts
• minimal or no sexual dysfunction
• minimal or no weight gain
• also see SSRI

• drug adverse effects of SSRIs
• drug adverse effects of antidepressants
• drug adverse effects of psychotropic agents

Drug interactions

• inhibitors of CYP3A4 may increase vilazodone levels
• vilazodone could potentially increase levels of drugs metabolized by CYP2C8

• drug interaction(s) of oral anticoagulants with selective serotonin reuptake inhibitor (SSRI)
• drug interaction(s) of antidepressant in combination with GLP1-agonist
• drug interaction(s) of ondanstetron with SSRIs
• drug interaction(s) of dextromethorphan with SSRIs
• drug interaction(s) of trazodone with SSRIs
• drug interaction(s) of tramadol with SSRIs
• drug interaction(s) of triptans with SSRIs
• drug interaction(s) of anti-platelet agents with SSRIs
• drug interaction(s) of methylene blue with SSRIs
• drug interaction(s) of linezolid with SSRIs
• drug interaction(s) of statins with SSRIs
• drug interaction(s) of hypericum perforatum (Sr John's wort) with SSRI
• drug interaction(s) of tamoxifen with SSRI
• drug interaction(s) of benzodiazepines with antidepressants
• drug interaction(s) of antidepressants with benzodiazepines
• drug interaction(s) of NSAIDs with SSRIs
• drug interaction(s) of NSAIDs with antidepressants
• drug interaction(s) of antidepressant with opiates
• drug interaction(s) of coxib with SSRI

Laboratory

• vilazodone in urine

Mechanism of action

• combined selective serotonin reuptake inhibitor & serotonin 1A receptor partial agonist

More general terms

• selective serotonin reuptake inhibitor (SSRI)

Additional terms

• serotonin [5HT]-1A receptor; 5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; serotonin receptor 1A; G-21 (HTR1A, ADRB2RL1, ADRBRL1)
• serotonin; 5-hydroxytryptamine