drug adverse effects of SSRIs

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Adverse effects

* diminished serotonin in platelets due to diminished uptake [2][3][6][9][18]

* patients with anxiety disorder should be counseled on potential of adverse effects & when they do occur are likely to be benign & shortlived, often a manifestation of the underlying disorder[25]

Complications

More general terms

References

  1. UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
  2. 2.0 2.1 Journal Watch 21(22):179, 2001 van Walraven C et al Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study. BMJ 323:655, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11566827
  3. 3.0 3.1 Prescriber's Letter 8(11):62 2001 Sauer WH et al Selective serotonin reuptake inhibitors and myocardial infarction. Circulation 104:1894, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11602490
  4. 4.0 4.1 Prescriber's Letter 9(7):38 2002
  5. 5.0 5.1 Journal Watch 22(16):127, 2002 Weintrob N et al Decreased growth during therapy with selective serotonin reuptake inhibitors. Arch Pediatr Adolesc Med 156:696, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12090838
  6. 6.0 6.1 Prescriber's Letter 10(3):14 2003
  7. 7.0 7.1 Journal Watch 23(13):106, 2003 Casper RC et al, Follow-up of children of depressed mothers exposed or not exposed to antidepressant drugs during pregnancy. J Pediatr 142:402, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12712058
  8. 8.0 8.1 Journal Watch 25(7):58, 2005 Sanz EJ, De-las-Cuevas C, Kiuru A, Bate A, Edwards R. Selective serotonin reuptake inhibitors in pregnant women and neonatal withdrawal syndrome: a database analysis. Lancet. 2005 Feb 5;365(9458):482-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15705457
  9. 9.0 9.1 Prescriber's Letter 12(7): 2005 Selective Serotonin Reuptake Inhibitors (SSRIs) and Antiplatelet Activity Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210715&pb=PRL (subscription needed) http://www.prescribersletter.com
  10. 10.0 10.1 Journal Watch 24(11):85, 2004 Whittington CJ, Kendall T, Fonagy P, Cottrell D, Cotgrove A, Boddington E. Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data. Lancet. 2004 Apr 24;363(9418):1341-5. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15110490 Jureidini JN, Doecke CJ, Mansfield PR, Haby MM, Menkes DB, Tonkin AL. Efficacy and safety of antidepressants for children and adolescents. BMJ. 2004 Apr 10;328(7444):879-83. Review. No abstract available. Erratum in: BMJ. 2004 May 15;328(7449):1170. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/15073072 <Internet> http://bmj.bmjjournals.com/cgi/content/full/328/7444/879
  11. 11.0 11.1 11.2 Journal Watch 25(8):65, 2005 Martinez C, Rietbrock S, Wise L, Ashby D, Chick J, Moseley J, Evans S, Gunnell D. Antidepressant treatment and the risk of fatal and non-fatal self harm in first episode depression: nested case-control study. BMJ. 2005 Feb 19;330(7488):389. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/15718538 <Internet> http://bmj.bmjjournals.com/cgi/content/full/330/7488/389
    Gunnell D, Saperia J, Ashby D. Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA's safety review. BMJ. 2005 Feb 19;330(7488):385. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/15718537 <Internet> http://bmj.bmjjournals.com/cgi/content/full/330/7488/385
    Fergusson D, Doucette S, Glass KC, Shapiro S, Healy D, Hebert P, Hutton B. Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials. BMJ. 2005 Feb 19;330(7488):396. Review. Erratum in: BMJ. 2005 Mar 19;330(7492):653. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/15718539 <Internet> http://bmj.bmjjournals.com/cgi/content/full/330/7488/396
    Cipriani A, Barbui C, Geddes JR. Suicide, depression, and antidepressants. BMJ. 2005 Feb 19;330(7488):373-4. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15718515
  12. Journal Watch 25(12):97, 2005 Moses-Kolko EL, Bogen D, Perel J, Bregar A, Uhl K, Levin B, Wisner KL. Neonatal signs after late in utero exposure to serotonin reuptake inhibitors: literature review and implications for clinical applications. JAMA. 2005 May 18;293(19):2372-83. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15900008
  13. 13.0 13.1 13.2 13.3 Levinson-Castiel R et al, Neonatal abstinence syndrome after in utero exposure to selective serotonin reuptake inhibitors in term infants. Arch Pediatr Adolisc Med 2006; 160:173 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16461873
    Chambers CD et al, Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn. N Engl J Med 2006; 354:579 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16461545
  14. 14.0 14.1 14.2 Prescriber's Letter 13(4): 2006 Use of Selective Serotonin Reuptake Inhibitor Medications During Pregnancy Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220408&pb=PRL (subscription needed) http://www.prescribersletter.com
  15. 15.0 15.1 Prescriber's Letter 13(5): 2006 How to Switch antidepressants Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220605&pb=PRL (subscription needed) http://www.prescribersletter.com
  16. 16.0 16.1 Diem SJ et al, Use of Antidepressants and Rates of Hip Bone Loss in Older Women - The Study of Osteoporotic Fractures Arch Intern Med. 2007;167:1240-1245.
    Haney EM et al, Association of Low Bone Mineral Density With Selective Serotonin Reuptake Inhibitor Use by Older Men Arch Intern Med. 2007;167:1246-1251
  17. 17.0 17.1 Gonul AS and Aksu M SSRI-induced parkinsonism may be an early sign of future Parkinson's disease. J Clin Psychiatry 1999, 60:410 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10401924
    Anonymous Extrpyramidal effects of SSRI antidepressants Prescrire 2001, 10:118 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11718183
    Vajda FJ and Solinas C Current approaches to management of depression in Parkinson's disease. J Clin Neurosci 2005, 12:739 PMID: https://www.ncbi.nlm.nih.gov/pubmed/15911816
  18. 18.0 18.1 de Abajo FJ, Garcia-Rodriguez LA. Risk of upper gastrointestinal tract bleeding associated with selective serotonin reuptake inhibitors and venlafaxine therapy: interaction with nonsteroidal anti-inflammatory drugs and effect of acid-suppressing agents. Arch Gen Psychiatry. 2008 Jul;65(7):795-803. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18606952
  19. 19.0 19.1 Targownik LE et al Selective serotonin reuptake inhibitors are associated with a modest increase in the risk of upper gastrointestinal bleeding. Am J Gastroenterol 2009 Jun; 104:1475. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19491861
  20. Smoller JW et al Antidepressant Use and Risk of Incident Cardiovascular Morbidity and Mortality Among Postmenopausal Women in the Women's Health Initiative Study Arch Intern Med. 2009;169(22):2128-2139. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/20008698 <Internet> http://archinte.ama-assn.org/cgi/content/short/169/22/2128
  21. 21.0 21.1 21.2 21.3 21.4 Medical Knowledge Self Assessment Program (MKSAP) 15, 19 American College of Physicians, Philadelphia 2009, 2021
  22. 22.0 22.1 Malm H et al. Selective serotonin reuptake inhibitors and risk for major congenital anomalies. Obstet Gynecol 2011 Jul; 118:111. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21646927
  23. 23.0 23.1 Croen LA et al. Antidepressant use during pregnancy and childhood autism spectrum disorders. Arch Gen Psychiatry 2011 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21874331
  24. 24.0 24.1 Kieler H et al. Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: Population based cohort study from the five Nordic countries. BMJ 2012 Jan 12; 344:d8012. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22240235 <Internet> http://dx.doi.org/10.1136/bmj.d8012
    Koren G and Nordeng H. SSRIs and persistent pulmonary hypertension of the newborn. BMJ 2012 Jan 12; 344:d7642 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22240234 <Internet> http://dx.doi.org/10.1136/bmj.d7642
  25. 25.0 25.1 25.2 25.3 25.4 25.5 Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010
    Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
  26. 26.0 26.1 26.2 26.3 Hackam DG et al Selective serotonin reuptake inhibitors and brain hemorrhage A meta-analysis Neurology. October 17, 2012 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23077009 <Internet> http://www.neurology.org/content/early/2012/10/17/WNL.0b013e318271f848.abstract
  27. 27.0 27.1 Stephansson O et al Selective serotonin reuptake inhibitors during pregnancy and risk of stillbirth and infant mortality. JAMA. 2013 Jan 2;309(1):48-54 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23280224
  28. 28.0 28.1 Wisner KL et al. Does fetal exposure to SSRIs or maternal depression impact infant growth? Am J Psychiatry 2013 Mar 20 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23511234 <Internet> http://ajp.psychiatryonline.org/article.aspx?articleID=1669748
  29. 29.0 29.1 Hviid A et al. Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. N Engl J Med 2013 Dec 19; 369:2406 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24350950 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1301449
  30. 30.0 30.1 Grigoriadis S et al Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: systematic review and meta-analysis. BMJ 2014;348:f6932 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24429387 <Internet> http://www.bmj.com/content/348/bmj.f6932
  31. 31.0 31.1 Roy-Byrne P Higher SSRI Doses Linked to Greater Risk for Self-Harm in Youth. NEJM Journal Watch. May 5, 2014 Massachusetts Medical Society (subscription needed) http://www.jwatch.org
    Miller M et al. Antidepressant dose, age, and the risk of deliberate self-harm. JAMA Intern Med 2014 Apr 28 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24782035 <Internet> http://archinte.jamanetwork.com/article.aspx?articleid=1863925
    Brent DA and Gibbons R. Initial dose of antidepressant and suicidal behavior in youth: Start low, go slow. JAMA Intern Med 2014 Apr 28 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24781493 <Internet> http://archinte.jamanetwork.com/article.aspx?articleid=1863917
  32. 32.0 32.1 Ayerbe L et al. Explanatory factors for the increased mortality of stroke patients with depression. Neurology 2014 Nov 25; 83:2007. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25355829 <Internet> http://www.neurology.org/content/83/22/2007
    Bartoli F and Paolucci S. Association of depression and SSRIs with mortality after stroke. Neurology 2014 Nov 25; 83:1998. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25355834 <Internet> http://www.neurology.org/content/83/22/1998
  33. 33.0 33.1 33.2 Furu K et al. Selective serotonin reuptake inhibitors and venlafaxine in early pregnancy and risk of birth defects: Population based cohort study and sibling design. BMJ 2015 Apr 17; 350:h1798 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25888213
  34. 34.0 34.1 Sheu YH et al. SSRI use and risk of fractures among perimenopausal women without mental disorders. Inj Prev 2015 Jun 25 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26113668
  35. 35.0 35.1 Malm H et al. Pregnancy complications following prenatal exposure to SSRIs or maternal psychiatric disorders: Results from population- based national register data. Am J Psychiatry 2015 Aug 4 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26238606 <Internet> http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2015.14121575
  36. 36.0 36.1 Boukhris T et al Antidepressant Use During Pregnancy and the Risk of Autism Spectrum Disorder in Children. JAMA Pediatr. Published online December 14, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26660917 <Internet> http://archpedi.jamanetwork.com/article.aspx?articleid=2476187
    King BH Assessing Risk of Autism Spectrum Disorder in Children After Antidepressant Use During Pregnancy. JAMA Pediatr. Published online December 14, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26660503 <Internet> http://archpedi.jamanetwork.com/article.aspx?articleid=2476185
  37. 37.0 37.1 37.2 Norby U, Forsberg L, Wide K et al. Neonatal morbidity after maternal use of antidepressant drugs during pregnancy. Pediatrics 2016 Oct 25; <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27940758 <Internet> http://pediatrics.aappublications.org/content/early/2016/10/21/peds.2016-0181
  38. 38.0 38.1 Knoll JL, Pies RW. The SSRI-Violence Link: Myth or Menace? Medscape - Aug 20, 2020. https://www.medscape.com/viewarticle/935846
  39. 39.0 39.1 Haddad YK, Kakara R, Marcum ZA. A comparative analysis of selective serotonin reuptake inhibitors and fall risk in older adults. J Am Geriatr Soc. February 8, 2022. PMID: https://www.ncbi.nlm.nih.gov/pubmed/35132611
  40. 40.0 40.1 NEJM Knowledge+