restless legs syndrome; Willis-Ekbom disease (RLS)

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Introduction

An irresistable urge to move the legs, especially at night, due to uncomfortable, crawling, dull, tingling sensations in the lower 1/2 of the legs that occurs at rest.

Etiology

Epidemiology

Genetics

  • genetic variations in BTBD9 may be associated with susceptibility to restless legs syndrome type 6
  • defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7

Clinical manifestations

Laboratory

Diagnostic procedures

* to evaluate associated disorder of nocturnal myoclonus

Complications

Differential diagnosis

Management

* Requip is the 1st drug FDA-approved for treatment of restless legs syndrome[8]

More general terms

Additional terms

References

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  34. NINDS Restless Legs Syndrome Information Page https://www.ninds.nih.gov/disorders/All-Disorders/Restless-Legs-Syndrome-Information-Page
    Restless Legs Syndrome Fact Sheet https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Restless-Legs-Syndrome-Fact-Sheet
    Facts About Restless Legs Syndrome (RLS) http://www.nhlbi.nih.gov/health/public/sleep/rls.htm

Patient information

restless legs syndrome (RLS) patient information

Database