amantadine; adamantamine (Symmetrel, Gocovri)

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Introduction

Tradename: Symmetrel.

Indications

Contraindications

pregnancy category = c

safety in lactation = ?

Dosage

Tabs: 100 mg.

Syrup: 50 mg/5 mL (480 mL).

Dosage adjustment in renal failure

Table

creatinine clearance dosage
> 50-90 mL/min every 24-48 hour dosing
10-50 mL/min every 48-72 hours dosing
< 10 mL/min* every 7 day dosing

* No additional dosing for hemodialysis

Pharmacokinetics

elimination via kidney

1/2life = 9-37 hours

protein binding = 67 %

elimination by hemodialysis = -

elimination by peritoneal dialysis = -

Adverse effects

Drug interactions

Mechanism of action

More general terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
  2. Jump up to: 2.0 2.1 AHFS 96 Drug Information, GK McEnvoy et al (ed), American Society of Health-System Pharmacists, Bethesda, MD 1996, pg 432, 2703
  3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Jump up to: 4.0 4.1 4.2 Prescriber's Letter 8(10):56 2001
  5. Sanford Guide to antimicrobial therapy 2001
  6. Prescriber's Letter 10(11) 2003; detail document 191102
  7. Jump up to: 7.0 7.1 7.2 Prescriber's Letter 11(1):1 2004
  8. Jump up to: 8.0 8.1 8.2 8.3 8.4 Bronstein J, In: Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 29-Oct 2, 2004
  9. Jump up to: 9.0 9.1 9.2 Bright RA, Medina MJ, Xu X, Perez-Oronoz G, Wallis TR, Davis XM, Povinelli L, Cox NJ, Klimov AI. Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern. Lancet. 2005 Oct 1;366(9492):1175-81. Epub 2005 Sep 22. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16198766
    Centers for Disease Control and Prevention (CDC). High levels of adamantane resistance among influenza A (H3N2) viruses and interim guidelines for use of antiviral agents: United States, 2005-06 influenza season. MMWR Morb Mortal Wkly Rep. 2006 Jan 20;55(2):44-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16424859
    Prescriber's Letter 13(2): 2006 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220202&pb=PRL (subscription needed) http://www.prescribersletter.com
    Bright RA et al, Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States. JAMA 2006 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16456807
    Centers for Disease Control and Prevention (CDC). CDC recommends against use of amantadine and rimantadine for the treatment of prophylaxis of influenza during the 2005- 2006 flu season. CDC Health Alert Network 2006, Jan 14 http://www.cdc.gov/flu/han011406.htm
  10. Jump up to: 10.0 10.1 10.2 Medical Knowledge Self Assessment Program (MKSAP) 15, 16. American College of Physicians, Philadelphia 2009, 2012
  11. Department of Veterans Affairs, VA National Formulary
  12. Jump up to: 12.0 12.1 Brooks M FDA Clears First Drug for Parkinson's Dyskinesia Medscape - Aug 25, 2017. http://www.medscape.com/viewarticle/884697

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