NMDA receptor antagonist

Introduction

High affinity NMDA receptor antagonist are generally toxic; however, several low-affinity NMDA receptor antagonists are in use as pharmaceutical agents:

• memantine
• dextromethorphan
• amantadine
• ketamine
• phencyclidine

Adverse effects

• NMDA receptor antagonists cause positive, negative, & cognitive symptoms similar to schizophrenia in animals & healthy individuals & worsen symptoms in schizophrenic patients

More general terms

• receptor antagonist

More specific terms

• amantadine; adamantamine (Symmetrel, Gocovri)
• dextromethorphan (Benylin DM)
• ketamine (Ketalar, special K)
• memantine (Auzura, Namenda, Exiba, Akatinol)
• phencyclidine; phenylcyclohexyl piperidine (Sernylan, PCP, angel dust)
• tiletamine

Additional terms

• NMDA receptor