ketamine (Ketalar, special K)

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Introduction

Tradename: Ketalar. DEA-controlled substance: class 3.

Indications

Contraindications

Caution:

pregnancy category = ?

safety in lactation = ?

Dosage

* Injection: 10 mg/mL (50 mL); 50 mg/mL (10 mL); 100 mg/mL (5 mL).

* Nebulizer 0.75-1.5 mg/kg[15]

Pharmacokinetics

elimination via liver

1/2life = 2-4 hours

protein binding = 20-50 %

Adverse effects

* treatmenot of ketamine-induced uropathy

Drug interactions

Laboratory

Mechanism of action

Notes

More general terms

More specific terms

Additional terms

References

  1. Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1995
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  5. Jump up to: 5.0 5.1 Prescriber's Letter 10(11) 2003; detail doceument 191102
  6. Jump up to: 6.0 6.1 Jabre P et al Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: A multicentre randomised controlled trial. Lancet 2009 Jul 1; <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19573904 <Internet> http://dx.doi.org/10.1016/S0140-6736(09)60949-1
    Wenzel V and Lindner KH. Best pharmacological practice in prehospital intubation. Lancet 2009 Jul 1; <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19573905 <Internet> http://dx.doi.org/10.1016/S0140-6736(09)61071-0
  7. Jump up to: 7.0 7.1 7.2 Bar-Joseph G et al. Effectiveness of ketamine in decreasing intracranial pressure in children with intracranial hypertension. J Neurosurg Pediatr 2009 Jul; 4:40. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19569909
  8. Jump up to: 8.0 8.1 Deprecated Reference
  9. Jump up to: 9.0 9.1 Motov S et al. Intravenous subdissociative-dose ketamine versus morphine for analgesia in the emergency department: A randomized controlled trial. Ann Emerg Med 2015 Mar 26 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25817884
  10. Jump up to: 10.0 10.1 Isbister GK. Ketamine as rescue treatment for difficult-to-sedate severe acute behavioral disturbance in the emergency department. Ann Emerg Med 2016 Feb 18 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26899459 <Internet> http://www.annemergmed.com/article/S0196-0644%2815%2901562-0/abstract
  11. Jump up to: 11.0 11.1 Sanacora G, Frye MA, McDonald W et al A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders. JAMA Psychiatry. 2017 Apr 1;74(4):399-405. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28249076
    Abbasi J Ketamine Minus the Trip: New Hope for Treatment-Resistant Depression. JAMA. Published online November 8, 2017 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29117311 https://jamanetwork.com/journals/jama/fullarticle/2662752
  12. Jump up to: 12.0 12.1 Brooks M First-Ever Ketamine Guidelines for Pain Management Released. Medscape - Jun 15, 2018. https://www.medscape.com/viewarticle/898134
  13. Jump up to: 13.0 13.1 Anand A et al. Ketamine versus ECT for nonpsychotic treatment-resistant major depression. N Engl J Med 2023 May 24; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37224232 https://www.nejm.org/doi/10.1056/NEJMoa2302399
    Freedman R. Ketamine and ECT in depression - Risks and rewards. N Engl J Med 2023 May 24; [e-pub] PMID: https://www.ncbi.nlm.nih.gov/pubmed/37224235 https://www.nejm.org/doi/10.1056/NEJMe2305130
  14. Jump up to: 14.0 14.1 14.2 Almodibeg B, Forget P Challenges of acute pain management in older patients. Age Ageing. 2024 Apr 1;53(4):afae061. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38557666 https://academic.oup.com/ageing/article/53/4/afae061/7638303
  15. Jump up to: 15.0 15.1 Dove D, Fassassi C, Davis A et al Comparison of Nebulized Ketamine at Three Different Dosing Regimens for Treating Painful Conditions in the Emergency Department: A Prospective, Randomized, Double-Blind Clinical Trial. Ann Emerg Med. 2021 Dec;78(6):779-787. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34226073 Clinical Trial.
  16. Jump up to: 16.0 16.1 Richeux V Ketamine-Induced Uropathy: What Urologists Need to Know. Medscape. January 21, 2025 https://www.medscape.com/viewarticle/ketamine-induced-uropathy-what-urologists-need-know-2025a10001dp
    Bourillon A, Cornu JN, Herve F et al Management of ketamine cystitis: National guidelines from the French Association of Urology (CUROPF/CTMH) Fr J Urol. 2024 Nov;34(14):102754 PMID: https://www.ncbi.nlm.nih.gov/pubmed/39368630 Free article https://www.sciencedirect.com/science/article/pii/S2950393024002110

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