general anesthesia
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Physiology
Effects of general inhalation anesthesia & muscle paralysis:
- reduced thoracic compliance
- lower residual capacity
- mismatching of ventilation/perfusion
Adverse effects
- may precipitate paroxysm of pheochromocytoma[1]
- elective surgery with general anesthesia
- not associated with increased risk for dementia[3]
- associated with increase risk of cognitive impairment in elderly Chinese
- conversion from normal cognition to mild cognitive impairment (MCI)
- relative risk = 1.5; absolute risk = 8.2%[4]
- conversion to MCI correlates with diminished volume of the right amygdala
- conversion from normal cognition to mild cognitive impairment (MCI)
More general terms
References
- ↑ 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 16. American College of Physicians, Philadelphia 1998, 2012
- ↑ Merry AF et al. Multimodal system designed to reduce errors in recording and administration of drugs in anaesthesia: Prospective randomised clinical evaluation. BMJ 2011 Sep 22; 343:d5543 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21940742
- ↑ 3.0 3.1 Velkers C et al Association Between Exposure to General Versus Regional Anesthesia and Risk of Dementia in Older Adults. J Am Geriatrics Soc, 2020 Oct 6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33025584 https://onlinelibrary.wiley.com/doi/10.1111/jgs.16834
- ↑ 4.0 4.1 Li W, Jiang J, Zhang S et al Prospective association of general anesthesia with risk of cognitive decline in a Chinese elderly community population. Sci Rep. 2023 Aug 18;13(1):13458 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37596302 PMCID: PMC10439205 Free PMC article https://www.nature.com/articles/s41598-023-39300-5