sedative/hypnotic (tranquilizer)
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Adverse effects
- increased mortality risk in patients taking sedative/ hypnotics 30 times in the past month
- increased mortality (2-fold increase in 8 year mortality)[3]
- repeated use of general anesthetics & sedatives, or use for > 3 hours, in children < 3 years of age & in women in the 3rd trimester of pregnancy could adversely affect child brain development[4]*
- prolonged exposure to sedative in children < 3 years of age may adversely affect brain development[5]
* ACOG takes issue with warning[4]
More general terms
More specific terms
- acepromazine; acetylpromazine (Atravet, Acezine 2)
- atipamezole (Antisedan)
- azatadine (Optimine)
- benzodiazepine
- brompheniramine (Dimetane)
- buspirone (BuSpar)
- butabarbital; secumalum; secbutabarbital (Butisol)
- butalbital; allylbarbital (Profundol, Sandoptal)
- carisoprodol (Soma, Rela)
- chloral [hydrate] (Noctec)
- chlormezanone (Trancopal)
- chlorpheniramine (Chlor-Trimeton)
- clemastine (Tavist)
- cyproheptadine (Periactin)
- daridorexant; nemorexant (Quviviq)
- detomidine (DORMOSEDAN)
- dexmedetomidine (Precedex)
- dichloralphenazone (Kloralfenazon)
- dimenhydrinate (Dramamine)
- diphenhydramine (Benadryl, Alledryl, Allergival)
- eszopiclone (Lunesta)
- ethchlorvynol (Placidyl)
- gamma-hydroxybutyrate; sodium oxybate (Xyrem, Xywav, Anetamin, Somsanit, Lumryz, date rape drug)
- glutethimide (Doriden)
- hydroxyzine (Atarax, Vistaril)
- mephobarbital (Mebaral)
- meprobamate (Equanil, Miltown)
- methapyrilene (Paradormalene)
- methaqualone (Quaalude, Mozambin)
- methyprylon (Noludar)
- opioid receptor agonist (narcotic)
- paraldehyde
- pentobarbital (Nembutal)
- pheniramine (Tripoton)
- propiomazine (Largon)
- secobarbital (Seconal)
- suvorexant (Belsomra)
- thiopental (Pentothal)
- triprolidine (Actidil)
- zaleplon (Sonata)
- zolpidem (Ambien, Zolpimist, Edluar, Intermezzo)
- zopiclone (Imovane, Zimovane)
Additional terms
References
- ↑ UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
- ↑ FDA MedWatch http://www.fda.gov/medwatch/safety/2007/safety07.htm#Sedative
- ↑ 3.0 3.1 Weich S et al Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort study. BMJ 2014;348:g1996 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24647164 <Internet> http://www.bmj.com/content/348/bmj.g1996
- ↑ 4.0 4.1 4.2 FDA Safety Alert. Dec 14, 2016 General Anesthetic and Sedation Drugs: Drug Safety Communication
New Warnings for Young Children and Pregnant Women. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm533195.htm
FDA Drug Safety Communication: Dec 14, 2016 FDA review results in new warnings about using general anesthetics and sedation drugs in young children and pregnant women. http://www.fda.gov/Drugs/DrugSafety/ucm532356.htm
American College of Obstetricians & Gynecologists. Dec 21, 2016 Practice Advisory: FDA Warnings Regarding Use of General Anesthetics and Sedation Drugs in Young Children and Pregnant Women. http://www.acog.org/About-ACOG/News-Room/Practice-Advisories/FDA-Warnings-Regarding-Use-of-General-Anesthetics-and-Sedation-Drugs - ↑ 5.0 5.1 FDA Safety Alert. April 27, 2017 General Anesthetic and Sedation Drugs: Drug Safety Communication
FDA Approves Label Changes for Use in Young Children. https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm555631.htm