sleeping pill
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Introduction
A generic term used for one of several different classes of medications used to treat insomnia. These include:
Classification
Epidemiology
Pharmacokinetics
- all start to work in about 30 minutes[3]
Complications
- increased mortality associated with chronic use
- amnesia[4]
- anaphylaxis[4]
- all increase the risk of falls in the elderly[6]
- increased risk of hip fractures
- rebound insomnia after discontinuation[6]
- use in later life increases risk for dementia (RR=1.5)[10] Manangement:
- identify the sleeping pill patient is using (melatonin is ok)
- screen for depression with PHQ9 as indicated[9]
- see insomnia
Notes
More general terms
More specific terms
- benzodiazepine
- Indiplon
- lemborexant (Dayvigo)
- sedative/hypnotic (tranquilizer)
- tasimelteon (VEC-162)
- trazodone (Desyrel, Pragmazone, Oleptro)
- Z drug
References
- ↑ UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
- ↑ UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 25-28, 2002
- ↑ 3.0 3.1 3.2 Prescriber's Letter 12(9): 2005 Comparison of Insomnia Treatments Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210901&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 4.0 4.1 4.2 Prescriber's Letter 14(4): 2007 FDA Requests Label Change for All Sleep Disorder Drug Products Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=230405&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 5.0 5.1 5.2 Kripke DF et al Hypnotics' association with mortality or cancer: a matched cohort study BMJ Open 2012;2:e000850 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22371848 <Internet> http://bmjopen.bmj.com/content/2/1/e000850.full
- ↑ 6.0 6.1 6.2 Geriatrics at your Fingertips, 13th edition, 2011 Reuben DB et al (eds) American Geriatric Society
- ↑ 7.0 7.1 Berry SD et al Nonbenzodiazepine Sleep Medication Use and Hip Fractures in Nursing Home Residents. JAMA Intern Med. 2013;():1-8 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23460413 <Internet> http://archinte.jamanetwork.com/article.aspx?articleid=1657760
Widera E What's to Blame for Falls and Fractures? Poor Sleep or the Sleeping Medication? JAMA Intern Med. 2013;():1-2 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23459766 <Internet> http://archinte.jamanetwork.com/article.aspx?articleid=1657762 - ↑ 8.0 8.1 Garcia J Long-term Use of Prescription Sleep Meds Unsupported by New Data. Medscape. May 19, 2021 https://www.medscape.com/viewarticle/951472
Solomon DH, Ruppert K, Habel LA et al Prescription medications for sleep disturbances among midlife women during 2 years of follow-up: a SWAN retrospective cohort study. BMJ Open. 2021 May 11;11(5):e045074 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33975865 Free PMC article. https://bmjopen.bmj.com/content/11/5/e045074 - ↑ 9.0 9.1 Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022
- ↑ 10.0 10.1 Full KM, Pusalavidyasagar S, Palta P et al Associations of late-life sleep medication use with incident dementia in the Atherosclerosis Risk in Communities (ARIC) Study. J Gerontol A Biol Sci Med Sci. 2022, April 13 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35421897 https://academic.oup.com/biomedgerontology/advance-article-abstract/doi/10.1093/gerona/glac088/6568591
- ↑ 11.0 11.1 11.2 Reuben C, Elgaddal N, Black LI Sleep Medication Use in Adults Aged 18 and Over: United States, 2020 NCHS Data Brief. No. 462. January 2023 https://www.cdc.gov/nchs/data/databriefs/db462.pdf