chlorpheniramine (Chlor-Trimeton)
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Introduction
Tradename: Chlor-Trimeton. (chlorpheniramine maleate)
Indications
- treatment of allergic reactions
- treatment of cold symptoms, cough, nasal congestion, rhinorrhea, sneezing[4]
Dosage
4 mg PO every 4-6 hours
Tabs: 2, 4, 8 mg
Syrup: 2 mg/5 mL.
Capsules: time-release: 8-12 mg PO BID.
Pharmacokinetics
- 1st pass metabolism
- 25-25% or oral dose reaches systemic circulation
- peak concentration occurs within 2-6 hours following oral administration
- 1/2life 12-40 hours
elimination via liver
elimination via kidney
1/2life = 12-40 hours
Adverse effects
- drug adverse effects of H1 receptor antagonists
- drug adverse effects of psychotropic agents
- drug adverse effects of sedatives
Drug interactions
- effects additive with other CNS depressants
- MAO inhibitors increase anticholinergic effects
Laboratory
Mechanism of action
histamine H1 receptor antagonist
More general terms
More specific terms
Component of
- atropine/chlorpheniramine/hyoscyamine/pseudoephedrine/scopolamine
- aspirin/chlorpheniramine/dextromethorphan/phenylephrine
- acetaminophen/chlorpheniramine/ephedrine/guaifenesin
- acetaminophen/chlorpheniramine/dextromethorphan/doxylamine/succinate
- acetaminophen/caffeine/chlorpheniramine/guaifenesin/n methylephedrine
- chlorpheniramine/pseudoephedrine/zinc acetate
- chlorpheniramine/phenylpropanolamine/pseudoephedrine
- chlorpheniramine/phenylephrine/scopolamine
- chlorpheniramine/methscopolamine/phenylephrine/zinc acetate
- chlorpheniramine/methscopolamine/phenylephrine/pseudoephedrine
- chlorpheniramine/methscopolamine/nitrate/phenylephrine
- chlorpheniramine/ibuprofen/phenylephrine
- chlorpheniramine/hyoscyamine/pseudoephedrine/scopolamine
- chlorpheniramine/hyoscyamine/phenylephrine/scopolamine
- chlorpheniramine/hyoscyamine/phenylephrine/phenylpropanolamine/scopolamine
- chlorpheniramine/hydrocodone/phenylephrine/pyrilamine
- chlorpheniramine/guaifenesin/phenylpropanolamine
- chlorpheniramine/guaifenesin/methscopolamine/phenylephrine
- chlorpheniramine/dextromethorphan/phenylephrine/phenylpropanolamine
- chlorpheniramine/dextromethorphan/guaifenesin/pseudoephedrine
- chlorpheniramine/dextromethorphan/guaifenesin/methscopolamine/phenylephrine
- chlorpheniramine/dextromethorphan/guaifenesin
- chlorpheniramine/codeine/phenylephrine/potassium iodide
- chlorpheniramine/codeine/phenylephrine
- chlorpheniramine/clemastine/pseudoephedrine
- chlorpheniramine/citrate/phenylephrine/phenyltoloxamine
- chlophedianol/chlorpheniramine/pseudoephedrine
- chlophedianol/chlorpheniramine/phenylephrine
- brompheniramine/chlorpheniramine/methscopolamine/phenylephrine/pseudoephedrine
- belladonna alkaloid/chlorpheniramine/pseudoephedrine
- acetaminophen/chlorpheniramine/phenylephrine/phenyltoloxamine
- acetaminophen/chlorpheniramine/guaifenesin/phenylephrine
- acetaminophen/chlorpheniramine/guaifenesin
- acetaminophen/chlorpheniramine/diphenhydramine/pseudoephedrine
- acetaminophen/chlorpheniramine/diphenhydramine/phenylephrine
- acetaminophen/chlorpheniramine/dextromethorphan/guaifenesin/phenylephrine
- acetaminophen/chlorpheniramine/dextromethorphan/doxylamine
- acetaminophen/chlorpheniramine/codeine/phenylephrine
- acetaminophen/caffeine/chlorpheniramine/phenylephrine
- acetaminophen/caffeine/chlorpheniramine/hydrocodone/phenylephrine
- acetaminophen/caffeine/chlorpheniramine/guaifenesin
- acetaminophen/caffeine/chlorpheniramine
- chlorpheniramine/phenylephrine/phenyltoloxamine
- chlorpheniramine/methscopolamine/pseudoephedrine
- chlorpheniramine/methscopolamine/phenylephrine
- chlorpheniramine/methscopolamine
- chlorpheniramine/dihydrocodeine/pseudoephedrine
- chlorpheniramine/dihydrocodeine/phenylephrine
- chlorpheniramine/dextromethorphan/methscopolamine
- carbetapentane/chlorpheniramine/phenylephrine
- carbetapentane/chlorpheniramine/ephedrine/phenylephrine
- carbetapentane/chlorpheniramine
- acetaminophen/chlorpheniramine/dextromethorphan/guaifenesin
- brompheniramine/chlorpheniramine/phenylephrine/pseudoephedrine
- chlorpheniramine/nitrate/phenylephrine
- chlorpheniramine/guaifenesin/phenylephrine
- chlorpheniramine/dextromethorphan/diethylcarbamazine/phenylephrine
- chlorpheniramine/hydrocodone (Tussionex)
- chlorpheniramine/hydrocodone/pseudoephedrine
- chlorpheniramine/guaifenesin/hydrocodone/pseudoephedrine
- carbohydrate/chlorpheniramine/dextromethorphan
- chlorpheniramine/dextromethorphan/guaifenesin/phenylephrine
- chlorpheniramine/ibuprofen/pseudoephedrine
- chlorpheniramine/hydrocodone/phenylephrine
- chlorpheniramine/dextromethorphan
- chlorpheniramine/codeine
- chlorpheniramine/dextromethorphan/pseudoephedrine
- chlorpheniramine/ephedrine/phenylephrine
- belladonna/belladonna alkaloid/chlorpheniramine/pseudoephedrine
- aspirin/chlorpheniramine/phenylephrine
- acetaminophen/chlorpheniramine/codeine
- acetaminophen/chlorpheniramine
- acetaminophen/chlorpheniramine/phenylephrine
- acetaminophen/chlorpheniramine/dextromethorphan
- acetaminophen/chlorpheniramine/dextromethorphan/pseudoephedrine
- acetaminophen/chlorpheniramine/dextromethorphan/phenylephrine
- acetaminophen/chlorpheniramine/pseudoephedrine
- acetaminophen/chlorpheniramine/phenylephrine/salicylamide
- chlorpheniramine/dextromethorphan/phenylephrine
- chlorpheniramine/phenylpropanolamine (Contac 12 hour, Ornade, Decongestant DT, Dura-Tap, Spansule)
- chlorpheniramine/phenylephrine (OMNIhist LA)
- chlorpheniramine/codeine/pseudoephedrine (Dihistine DH, Novahistine DH)
- chlorpheniramine/phenylephrine/pyrilamine (Triotann)
- chlorpheniramine/phenylephrine/phenylpropanolamine/phenyltoloxamine (Naldecon, Naldelate, Par Decon)
- insect sting or anaphylaxis kit (Ana-Kit)
- chlorpheniramine/pseudoephedrine (Deconamine, Kronofed)
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
- ↑ Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
- ↑ 4.0 4.1 Deprecated Reference