chlorpheniramine/phenylephrine/phenylpropanolamine/phenyltoloxamine (Naldecon, Naldelate, Par Decon)

Indications

• symptomatic treatment of nasal & eustachian tube congestion associated with sinusitis & upper respiratory tract infection
• symptomatic relief of allergic rhinitis

Contraindications

• severe hypertension
• coronary artery disease
• concurrent MAO inhibitor therapy

Dosage

• adults & children > 12 years: 1 tab TID
• children 6-12 years: 2.5 mL of syrup every 3-4 hours

Tabs: (sustained release)

phenylpropanolamine HCl 40 mg, chlorpheniramine maleate 5 mg

phenyltoloxamine citrate 15 mg & phenylephrine HCl 10 mg

Syrup:

phenylpropanolamine HCl 20 mg, chlorpheniramine maleate 2.5 mg

phenyltoloxamine citrate 7.5 mg & phenylephrine HCl 5 mg/5 mL Pediatric syrup:

phenylpropanolamine HCl 5 mg, chlorpheniramine maleate 0.5 mg

phenyltoloxamine citrate 2 mg & phenylephrine HCl 1.25 mg/5 mL

Adverse effects

• drowsiness
• sedation
• dizziness

More general terms

• Ear nose throat combination

Components

• chlorpheniramine (Chlor-Trimeton)
• phenylephrine (Neo-Synephrine, Mydrifin, sudafed PE, PE)
• phenylpropanolamine (PPA)
• phenyltoloxamine

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=196241