drug adverse effects of parasympatholytics
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Adverse effects
- dry skin, dry mucous membrames, dry mouth
- mydriasis, blurred vision
- urinary retention
- risk of acute urinary retention greatest in 1st 30 days of therapy[4]
- constipation
- abdominal pain
- tachycardia
- dizziness
- drowsiness
- nausea
- confusion, delirium
- hyperthermia
- thirst
- chronic use may increase risk of dementia[1][5]
- use of anticholinergics by cognitively nornal elderly is associated with increased brain atrophy & dysfunction & clinical decline[4]
- withdrawal: abrupt cessation can lead to cholinergic rebound symptoms,
More general terms
References
- ↑ 1.0 1.1 Carriere I et al Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: The 3-city study. Arch Intern Med 2009 Jul 27; 169:1317. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19636034
- ↑ Martin-Merino E et al. Do oral antimuscarinic drugs carry an increased risk of acute urinary retention? J Urol 2009 Oct; 182:1442. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19683302
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
- ↑ 4.0 4.1 4.2 Risacher SL, McDonald BC, Tallman EF et al Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults. JAMA Neurol. 2016 Jun 1;73(6):721-32. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27088965
- ↑ 5.0 5.1 Richardson K, Fox C, Maidment I et al Anticholinergic drugs and risk of dementia: case-control study. BMJ 2018;361:k1315 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29695481 Free PMC Article https://www.bmj.com/content/361/bmj.k1315
Gray SL, Hanlon JT Anticholinergic drugs and dementia in older adults BMJ 2018;361:k1722 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29695471 https://www.bmj.com/content/361/bmj.k1722 - ↑ 6.0 6.1 Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022
- ↑ Cross AJ, George J, Woodward MC et al Potentially Inappropriate Medications and Anticholinergic Burden in Older People Attending Memory Clinics in Australia. Drugs Aging. 2016 Jan;33(1):37-44 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2664529
- ↑ Reppas-Rindlisbacher CE, Fischer HD, Fung K et al Anticholinergic Drug Burden in Persons with Dementia Taking a Cholinesterase Inhibitor: The Effect of Multiple Physicians. J Am Geriatr Soc. 2016;64(3):492-500 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27000323 PMCID: PMC4819524 Free PMC article