buspirone (BuSpar)

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Introduction

Tradename: BuSpar.

Indications

  • generally considered drug of choice in the initial treatment of anxiety
  • especially useful for patients with history of chemical dependence - little potential for abuse
  • not for acute anxiety

Contraindications

Caution:

pregnancy category = b

safety in lactation = -

Advantages

Disadvantages

  • very slow to work (2-4 weeks)
  • not always effective
  • adverse effects

Dosage

  • start 5 mg PO TID (after meals)
  • increase by 5 mg every 2-3 days
  • max 60 mg/day
  • most patients respond to 15-30 mg QD

Tabs: 5 & 10 mg.

Pharmacokinetics

elimination via liver

elimination via kidney

protein binding = >95 %

elimination by hemodialysis = -

Adverse effects

Drug interactions

Laboratory

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 1120
  3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  5. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995

Database