methyprylon (Noludar)

Introduction

Tradename: Noludar. DEA-controlled substance: class 3.

Dosage

200-400 mg PO QHS

Tabs: 200 & 300 mg.

Pharmacokinetics

• metabolized in liver to multiple products, some with pharmacologic activity
• t1/2 of 4 hours, prolonged to 50 hours with acute overdose

elimination via liver

1/2life = 4 hours

elimination by hemodialysis = -

elimination by hemoperfusion = +

elimination by peritoneal dialysis = +/-

Adverse effects

• drowsiness
• ataxia
• acute overdose
  • coma
  • hypotension
  • shock

• drug adverse effects of psychotropic agents
• drug adverse effects of sedatives

Laboratory

• specimen: serum
• methods: GLC, color

More general terms

• sedative/hypnotic (tranquilizer)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4162