glutethimide (Doriden)
Jump to navigation
Jump to search
Introduction
Tradename: Doriden. DEA-controlled substance: class 3.
Dosage
Tabs: 200 & 500 mg.
Pharmacokinetics
- highly lipid soluble
- absorption from GI tract is erratic
- extensively metabolized in the liver
- 4-OH metabolite is active
- 2% of dose excreted unchanged into the urine
- extensive enterohepatic recirculation
- glutethimide is a potent stimulator of cyt P450
elimination via liver
1/2life = 5-22 hours
protein binding = 50 %
elimination by hemodialysis = -
elimination by hemoperfusion = +
elimination by peritoneal dialysis = -
Adverse effects
- excitement
- blurring of vision
- gastric irritation
- headache
- skin rash
- respiratory depression, circulatory collapse & coma occur with overdose
- osteomalacia may occur with chronic use