chloral [hydrate] (Noctec)

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Introduction

Tradename: Noctec. (trichloroacetaldehyde monohydrate) DEA-controlled substance: class 4.

Indications

Contraindications

recovered alcoholics

pregnancy category = c

safety in lactation = ?

Dosage

25-50 mg/kg up to 1000 mg PO Max 75 mg/kg.

Tabs: 250 & 500 mg.

Syrup: 250 & 500 mg/5 mL.

Suppositories: 345, 500, 648 mg.

Pharmacokinetics

  • well absorbed after oral administration
  • peak effect within 30 minutes to 1 hour
  • duration of action 4-8 hours
  • metabolized by liver to active metabolite trichloroethanol (active metabolite)

elimination via liver

elimination via kidney

1/2life = 4 min

1/2life = 4-14 hours trichloroethanol

protein binding = 35 % trichloroethanol

elimination by hemodialysis = +

elimination by hemoperfusion = +

Adverse effects

Drug interactions

Laboratory

Mechanism of action

CNS depressant

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995

Database