glutamate receptor 4; GluR-4; GluR4; GluR-D; glutamate receptor ionotropic, AMPA 4; AMPA-selective glutamate receptor 4 (GRIA4 GLUR4)

Function

• ionotropic glutamate receptor
• binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, & thereby converts the chemical signal to an electrical impulse
• the receptor then desensitizes rapidly & enters a transient inactive state, characterized by the presence of bound agonist
• palmitoylated
  • depalmitoylated upon glutamate stimulation
  • Cys-611 palmitoylation leads to Golgi retention & decreased cell surface expression
  • in contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation- dependent endocytosis (putative)
• interacts with EPB41L1 via its C-terminus (putative)
• receptor binds AMPA (quisqualate) > glutamate > kainate

Structure

• homotetramer or heterotetramer of pore-forming glutamate receptor subunits
• tetramers may be formed by the dimerization of dimers
• belongs to the glutamate-gated ion channel (TC 1.A.10) family

Compartment

• cell membrane
• cell junction, synapse, postsynaptic cell membrane

More general terms

• ionotropic receptor subunit

Database

• OMIM: https://mirror.omim.org/entry/138246
• UniProt: http://www.uniprot.org/uniprot/P48058.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2893