cell adhesion molecule 1; immunoglobulin superfamily member 4; nectin-like protein 2; NECL-2; tumor suppressor in lung cancer 1; TSLC-1; synaptic cell adhesion molecule; spermatogenic immunoglobulin superfamily; SgIGSF (CADM1, IGSF4, NECL2, SYNCAM, TSLC1)

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Function

mediates homophilic cell-cell adhesion (Ca+2-independent)
also mediates heterophilic cell-cell adhesion with CADM3 & PVRL3 (Ca+2-independent)
acts as tumor suppressor in non-small-cell lung cancer cells
interaction with CRTAM promotes
- NK cell cytotoxicity & IFN-gamma secretion by CD8+ cells in vitro
- NK cell-mediated rejection of tumors expressing CADM3 in vivo
may contribute to the less invasive phenotypes of lepidic growth tumor cells
in mast cells, may mediate attachment to & promote communication with nerves
CADM1, together with MITF, is essential for development & survival of mast cells in vivo
synaptic cell adhesion molecule that plays a role in formation of dendritic spines & drives synapse assembly
role in neuronal migration, axon growth, pathfinding, & fasciculation on the axons of differentiating neurons
glycosylation at Asn-67 & Asn-101 promotes adhesive binding & synapse induction
diverse roles in spermatogenesis including
- adhesion of spermatocytes & spermatids to Sertoli cells
- normal differentiation into mature spermatozoa
interacts with CRTAM
interacts with EPB41L3/DAL1 via C-terminus
interaction with EPB41L3/DAL1 may act to anchor CADM1 to actin cytoskeleton
interacts via its C-terminus with the PDZ domain of MPP3 & the PDZ domain of MPP6.

homodimer
cytoplasmic domain appears to play a critical role in proapoptosis & tumor suppressor activity in NSCLC
belongs to the nectin family
contains 2 Ig-like C2-type domains (immunoglobulin-like)
contains 1 Ig-like V-type domains (immunoglobulin-like)

absent or down-regulated in many advanced cases of NSCLC as well as in many other human cancers, due to gene silencing by promoter methylation
may contribute to less invasive phenotypes of lepidic growth tumor cells