cell adhesion molecule 3 (immunoglobulin superfamily member 4B, nectin-like protein 1, TSLC1-like protein 1. synaptic cell adhesion molecule 3, brain immunoglobulin receptor, CADM3, IGSF4B, NECL1, SYNCAM3, TSLL1)
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Function
- role in cell-cell adhesion
- Ca+2-independent homophilic cell-cell adhesion activity & Ca+2-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 & PVRL3
- interaction with EPB41L1 may regulate structure or function of cell-cell junctions
- interacts with EPB41L1, DLG3, MPP6 & CASK
Structure
- homodimer
- can form trans-heterodimers with PVRL3/nectin-3
- belongs to the nectin family
- contains 2 Ig-like C2-type domains (immunoglobulin-like)
- contains 1 Ig-like V-type domains (immunoglobulin-like)
Compartment
- cell junction
- localized at cell-cell attached sites of the plasma membrane
Alternative splicing
named isoforms=3
Expression
- isoform 1 is expressed mainly in adult & fetal brain
- isoform 2 is highly expressed in adult brain & weakly expressed in placenta
- in brain, Isoform 2 is highly expressed in cerebellum
Pathology
- induced in glioma cell lines & prostate cancer cell lines