CD111; poliovirus receptor-related protein 1; Herpes virus entry mediator C; Herpesvirus entry mediator C; HveC; Herpesvirus Ig-like receptor; HIgR; nectin-1 (PVRL1, HVEC, PRR1)

Function

• cell adhesion
• promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers
• heterophilic interactions have been detected between PVRL1/nectin-1 & PVRL3/nectin-3 & between PVRL1/nectin-1 & PVRL4/nectin-4
• can form trans-heterodimers with PVRL3/nectin-3 & with PVRL4/nectin-4
• interacts (via C-terminus) with afadin (via PDZ domain); this interaction recruits PVRL1 to cadherin-based adherens junctions
• interacts with integrin alphaV/beta3
• component of the adherens junction

Structure

• belongs to the nectin family
• contains 2 Ig-like C2-type domains
• contains 1 Ig-like V-type domain

Compartment

• isoforms alpha & delta:
  • cell membrane; single-pass type 1 membrane protein
• isoform gamma: secreted

Alternative splicing

named isoforms=3; alpha, gamma, delta

Expression

• widely expressed
• myeloid, monocyte, megakaryocytes & erythroid lineage
• epithelial cells
• neurons
• endothelium

Pathology

• receptor for herpes simplex viruses 1 & 2 & pseudorabies virus
  • functions as an entry receptor for these viruses
• mutations associated with:
  • ectodermal dysplasia type 4 (ED4) or Margarita island type of ectodermal dysplasia with cleft lip/palate
  • cleft lip/palate-ectodermal dysplasia syndrome (CLPED1) or Zlotogora-Ogur syndrome

More general terms

• CD antigen
• adhesion receptor
• immunoglobulin superfamily protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5818
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5818
• OMIM: https://mirror.omim.org/entry/225060
• OMIM: https://mirror.omim.org/entry/600644
• UniProt: http://www.uniprot.org/uniprot/Q15223.html