poliovirus receptor-related protein 3 (nectin-3, CD113 antigen, CDw113, PVRL3, PRR3)

Function

• role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins
  • trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions
  • trans-interaction with PVR induces activation of CDC42 & RAC small G proteins through common signaling molecules. i.e. SRC & RAP1
• role in formation of cell-cell junctions, including adherens junctions & synapses
• induces endocytosis-mediated down-regulation of PVR from cell surface, resulting in reduction of cell movement & proliferation
• role in morphology of ciliary body
• can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR, IGSF4B/Necl-1 & with IGSF4
• interacts with MLLT4/afadin

Structure

• cis- & trans-homodimer
• belongs to the nectin family
• contains 2 Ig-like C2-type domains (immunoglobulin-like)
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• predominantly expressed in testis & placenta
• expressed in many cell lines, including epithelial cell lines

More general terms

• CD antigen
• adhesion protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/607147
• UniProt: http://www.uniprot.org/uniprot/Q9NQS3.html