CD112; poliovirus receptor-related protein 2; Herpes virus entry mediator B; nectin 2 (PVRL2, HVEB, PRR2)

Function

• cell adhesion
• component of the adherens junction
• can form trans-heterodimers with PVRL3/nectin-3
• interacts with CD226
• binds with low affinity to TIGIT

Structure

• belongs to the nectin family
• contains 2 Ig-like C2-type domains
• contains 1 Ig-like V-type domain

Compartment

• cell membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2; alpha, delta

Expression

ubiquitous

Pathology

• interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) & pseudorabies virus (PRV) envelope glycoprotein
  • functions as an entry receptor for these viruses

More general terms

• CD antigen
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5819
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5819
• OMIM: https://mirror.omim.org/entry/600798
• UniProt: http://www.uniprot.org/uniprot/Q92692.html