CD226; DNAX accessory molecule 1; platelet & T cell activation antigen 1 (PTA1, DNAM1)

Function

• mediates intercellular adhesion
• lymphocyte signaling
• cytotoxicity
• lymphokine secretion mediated by cytotoxic T lymphocytes
• phosphorylated
• interacts with PVR & PVRL2

Structure

• contains 2 Ig-like C2-type domain (immunoglobulin-like)

Compartment

• membrane; single-pass type 1 membrane protein (putative)

Expression

• NK cells
• platelets
• monocytes
• subset of B-cells & T-cells
• negative antibody staining:
  • granulocytes
  • erythrocytes

More general terms

• CD antigen
• receptor
• phosphoprotein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10666
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10666
• OMIM: https://mirror.omim.org/entry/605397
• UniProt: http://www.uniprot.org/uniprot/Q15762.html