cytotoxic & regulatory T-cell molecule; class-I MHC-restricted T-cell-associated molecule; CD355 (CRTAM)
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Function
- interaction with CADM1 promotes
- NK cell cytotoxicity & IFN-gamma secretion by CD8+ cells in vitro
- NK cell-mediated rejection of tumors expressing CADM3 in vivo
- interacts with CADM1
Structure
- belongs to the nectin family
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment
membrane
Alternative splicing
named isoforms=2
Expression
- in the immune system, expression is restricted to activated class-1 MHC-restricted cells, including NKT & CD8 cells
- strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, & in Purkinje neurons in cerebellum
- expressed at much lower levels in testis, ovary, colon, lung & lymphoid tissues
More general terms
References
- ↑ Kennedy J, Vicari AP, Saylor V, Zurawski SM, Copeland NG, Gilbert DJ, Jenkins NA, Zlotnik A. A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). J Leukoc Biol. 2000 May;67(5):725-34. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10811014
- ↑ Galibert L, Diemer GS, Liu Z, Johnson RS, Smith JL, Walzer T, Comeau MR, Rauch CT, Wolfson MF, Sorensen RA, Van der Vuurst de Vries AR, Branstetter DG, Koelling RM, Scholler J, Fanslow WC, Baum PR, Derry JM, Yan W. Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I restricted T-cell associated molecule. J Biol Chem. 2005 Mar 21; [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/15781451
- ↑ Boles KS, Barchet W, Diacovo T, Cella M, Colonna M. The tumor suppressor TSLC1/NECL-2 triggers NK cell and CD8+ T cell responses through the cell surface receptor CRTAM. Blood. 2005 Apr 5; [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/15811952
- ↑ UniProt http://www.uniprot.org/uniprot/O95727.html