gastrin/cholecystokinin type B receptor; CCK-B receptor; CCK-BR; cholecystokinin-2 receptor; CCK2-R (CCKBR, CCKRB)

Function

• receptor for gastrin & cholecystokinin
• the CKK-B receptors occur throughout the CNS where they modulate anxiety, analgesia, arousal, & neuroleptic activity
• mediates its action by association with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
• isoform 2 may regulate cancer cell proliferation via a gastrin-independent mechanism

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Alternative splicing

named isoforms=3

Expression

• isoform 1 is expressed in brain, pancreas, stomach,
• within the stomach, expressed at high levels in the mucosa of the gastric fundus & at low levels in the antrum & duodenum
• isoform 1 is not expressed in heart, placenta, liver, lung, skeletal muscle, or kidney
• isoform 3 is expressed in brain, pancreas, stomach

Pathology

• isoform 1 is expressed in the colon cancer cell line LoVo & the T-lymphoblastoma Jurkat, but not in the stomach cancer cell line AGS
• expressed at high levels in the small cell lung cancer cell line H510, at lower levels in H345, H69 & GLC28
• not expressed in GLC19
• isoform 2 is present in pancreatic cancer cells & colorectal cancer cells, but not in normal pancreas or colonic mucosa
• isoform 3 is expressed in the stomach cancer cell line AGS & the colon cancer cell line LoVo; it is also expressed in normal stomach

More general terms

• G-protein coupled receptor; serpentine receptor
• cholecystokinin [CCK] receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:887
• OMIM: https://mirror.omim.org/entry/118445
• UniProt: http://www.uniprot.org/uniprot/P32239.html