cholecystokinin-pancreozymin (CCK)

Function

• dual action
  • induces gall bladder contraction
  • stimulates exocrine pancreatic enzyme secretion
• function in the brain is not clear
• binding to CCK-A receptors stimulates amylase release from the pancreas
• binding to CCK-B receptors stimulates gastric acid secretion
• precursor is cleaved by proteases to produce a number of active cholecystokinins
• binds to CCK-A receptors in the pancreas & CCK-B receptors in the brain (putative)

Structure

• CCK occurs in several different molecular forms
• a sulfotyrosine residue is required for biological activity

Expression

• secreted by epithelial cells within the small intestine in response to ingestion of food

Pharmacology

• sincalide is a synthetically-prepared C-terminal octapeptide of cholecystokinin used as a diagnostic agent

More general terms

• secreted protein
• gastrointestinal hormone

Additional terms

• cholecystokinin (CCK)/pancreozymin in plasma
• cholecystokinin [CCK] receptor
• sincalide (Kinevac)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=885
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:885
• OMIM: https://mirror.omim.org/entry/118440
• UniProt: http://www.uniprot.org/uniprot/P06307.html