cholecystokinin receptor type A; CCK-A receptor; CCK-AR; cholecystokinin-1 receptor; CCK1-R (CCKAR, CCKRA)

Function

• receptor for cholecystokinin
• mediates pancreatic growth & enzyme secretion
• mediates smooth muscle contraction of the gall bladder & stomach
• affinity 1000-fold higher for CCK than for gastrin
• modulates feeding & dopamine-induced behavior in the central nervous system & peripheral nervous system
• mediates its action via G proteins that activate a phosphatidylinositol-Ca+2 second messenger system

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane; multi-pass membrane protein

More general terms

• G-protein coupled receptor; serpentine receptor
• cholecystokinin [CCK] receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:886
• OMIM: https://mirror.omim.org/entry/118444
• UniProt: http://www.uniprot.org/uniprot/P32238.html