drug interaction(s) of antidepressant with opiates

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^[1]

Drug interactions

combination of CYP2D6-metabolized opiates* with CYP2D6-inhibiting antidepressants* is associated with worsening pain increased risk of opioid-related adverse events among older nursing home residents^[1]

* - CYP2D6-metabolized opiates

hydrocodone, codeine, tramadol, oxycodone

* - CYP2D6-inhibiting antidepressants

fluoxetine, paroxetine, duloxetine, doxepin, bupropion

More general terms

drug interaction

References

↑ ^1.0 ^1.1 Wei YJJ et al Clinical and Adverse Outcomes Associated With Concomitant Use of CYP2D6-Metabolized Opioids With Antidepressants in Older Nursing Home Residents. A Target Trial Emulation Study. Ann Intern Med. 2024. July 23 PMID: https://www.ncbi.nlm.nih.gov/pubmed/39038293 https://www.acpjournals.org/doi/10.7326/M23-3109

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