doxepin (Sinequan, Adapin, Zonalon, Silenor)

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Introduction

Tradenames: Adapin, Sinequan, Zonalon (topical) (Doxepin HCl)

Indications

Contraindications

Caution:

pregnancy category = c

pregnancy category = b

safety in lactation = -

Dosage

Antidepressant: start 75 mg PO BID/TID; max 400 mg/day

Pruritus: apply BID

Tabs: 10, 25, 50, 75, 100, 150 mg.

Silenor: 3, 6 mg for insomnia[7]

Liquid: 10 mg/mL.

Topical: cream 5%.

Pharmacokinetics

elimination via liver

protein binding = 80 %

elimination by hemodialysis = -

elimination by peritoneal dialysis = -

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. 2.0 2.1 Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. 3.0 3.1 Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  5. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 56
  6. Prescriber's Letter 17(10): 2010 COMMENTARY: Oleptro (Trazodone) and Silenor (Doxepin) CHART: Comparison of Insomnia Treatments Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=261005&pb=PRL (subscription needed) http://www.prescribersletter.com
  7. 7.0 7.1 7.2 7.3 Deprecated Reference
  8. 8.0 8.1 Goldstein JN, Dudzinski DM, Erickson TB, Linder G. Case 12-2018: A 30-Year-Old Woman with Cardiac Arrest. N Engl J Med 2018; 378:1538-1549. April 19, 2018 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29669228 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMcpc1800322
  9. 9.0 9.1 9.2 Talebraza S et al Geriatrics Evaluation & Management Tools American Geriatrics Society. 2021 https://geriatricscareonline.org/ProductAbstract/geriatrics-evaluation-management-tools/B007/

Database