serotonin [5HT]-1A receptor; 5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; serotonin receptor 1A; G-21 (HTR1A, ADRB2RL1, ADRBRL1)

Function

• one of the several receptors for 5-hydroxytryptamine (serotonin
• presynaptic autoreceptor
• interaction with serotonin turns off further release of serotonin
• only presynaptic serotonin receptor
• activity is mediated by G proteins that inhibit adenylate cyclase act(Gi proteins)

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane
• presynaptic autoreceptor on cell body & dendrites

More general terms

• serotonin [5HT]-1 receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3350
• OMIM: https://mirror.omim.org/entry/109760
• UniProt: http://www.uniprot.org/uniprot/P08908.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3350