paclitaxel (Taxol)

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Introduction

Tradenames: Taxol, Abraxane.

Indications

Dosage

Injection: in polyethoxylated castor oil (Camophor EL) 50% & alcohol: 6 mg/mL (5 mL).

Abraxane: solvent-free, albumin-bound formulation

Pharmacokinetics

elimination via liver

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

More specific terms

Additional terms

Component of

References

  1. Wahl et al Nature Medicine 2:72 1996
  2. 2.0 2.1 Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. 3.0 3.1 3.2 3.3 3.4 Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 17. American College of Physicians, Philadelphia 1998, 2012, 2015
  4. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  5. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
  6. Prescriber's Letter 13(2): 2006 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220215&pb=PRL (subscription needed) http://www.prescribersletter.com
  7. 7.0 7.1 7.2 Deprecated Reference
  8. Perez EA, Suman VJ, Davidson NE et al Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J Clin Oncol. 2008 Mar 10;26(8):1231-8 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18250349
  9. 9.0 9.1 Bassett M Cryotherapy May Help Prevent Neuropathy in Cancer Patients. Less CIPN in patients wearing ice-cold gloves and socks after taxane therapy. MedPage Today. October 12, 2017 https://www.medpagetoday.com/HematologyOncology/Chemotherapy/68498
    Hanai A, Ishiguro H, Sozu T et al Effects of Cryotherapy on Objective and Subjective Symptoms of Paclitaxel-Induced Neuropathy: Prospective Self-Controlled Trial. JNCI: J Natl Cancer Institute, 110(2) Feb 1 2018 Not indexed in PubMed https://academic.oup.com/jnci/article/4443215/Effects-of-Cryotherapy-on-Objective-and-Subjective

Database