anti-emetic
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Notes
- hydration is probably the most effective antiemetic[1]
- droperidol is better than placebo[1], but metoclopramide & prochlorperazine are NOT
- high-emetic-risk chemotherapy
- cisplatin or anthracycline combined with cyclophosphamide
- 4 drug combination of:
- substance P receptor antagonist (aprepitant or netupitant)
- 5-HT3 receptor anagonist (ondasetron or palonsetron)
- dexamethasone
- olanzapine
- continue dexamethasone & olanzapine on days 2-4[3]
- moderate-emetic-risk chemotherapy
- carboplatin, oxaliplatin
- 3 drug combination of
- substance P receptor antagonist (aprepitant or netupitant)
- 5-HT3 receptor anagonist (ondasetron or palonsetron)
- dexamethasone[3]
- breakthrough nausea/vomiting
- intravenous palonsetron + dexamethasone [NEJM Knowledge+,5,6]
- olanzapine[3]
- aprepitant, lorazepam, a dopamine receptor antagonist, dronabinol, or nabilone in patients with continued nausea/vomiting despite adequate hydration & olanzapine[3]
- high-emetic risk radiation therapy
- 2 drug combination before each fraction & on the day after each fraction
- 5-HT3 receptor anagonist (ondasetron)
- dexamethasone[3]
- 2 drug combination before each fraction & on the day after each fraction
- concurrent radiation & chemotherapy
- children:
- 3 drug combination of
- substance P receptor antagonist (aprepitant)
- 5-HT3 receptor anagonist (ondasetron)
- dexamethasone[3]
- ondansetron + dexamethasone if aprepitant contraindicated
- palonosetron + aprepitant if dexamethasone contraindicated
- 3 drug combination of
More general terms
More specific terms
- acepromazine; acetylpromazine (Atravet, Acezine 2)
- amisulpride (Solian, Deniban, Barhemsys)
- aprepitant (Emend)
- dimenhydrinate (Dramamine)
- diphenhydramine (Benadryl, Alledryl, Allergival)
- dolasetron (Anzemet)
- doxylamine (UniSom)
- dronabinol (Marinol)
- droperidol (Inapsine)
- fosaprepitant (Emend)
- granisetron (Kytril, Sancuso)
- intravenous anti-emetic combination
- maropitant (Cerenia)
- meclizine (Antivert)
- metoclopramide (Reglan, Metozolv ODT)
- nabilone (Cesamet)
- netupitant; fosnetupitant
- ondansetron (Zofran)
- palonosetron (Aloxi)
- phosphorylated carbohydrates (Emetrol)
- prochlorperazine (Compazine, Stemetil, Novamin, Buccastem)
- promethazine (Phenergan, Farganesse)
- rolapitant (Varubi)
- scopolamine (Transderm Scop, Hyoscine)
- suppository anti-emetic combination (BRD)
- thiethylperazine (Torecan, Norzine, Toresten)
- trimethobenzamide (Tigan)
- tropisetron (Navoban, Setrovel)
References
- ↑ 1.0 1.1 1.2 Braude D, Soliz T, Crandall C, Hendey G, Andrews J, Weichenthal L. Antiemetics in the ED: a randomized controlled trial comparing 3 common agents. Am J Emerg Med. 2006 Mar;24(2):177-82. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16490647
- ↑ Prescriber's Letter 13(10): 2006 Antiemetics Used for Postoperative Nausea and Vomiting Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=221004&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Anello J, Feinberg B, Heinegg J et al Antiemetics in Adults and Children Guidelines on antiemetics by the American Society of Clinical Oncology. Medscape: New Guidelines and Recommendations, August 2017. http://reference.medscape.com/viewarticle/884517
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 19. American College of Physicians, Philadelphia 2021
- ↑ Hesketh PJ, Kris MG, Basch E et al Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol. 2017 Oct 1;35(28):3240-3261. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28759346 Review.
- ↑ Navari RM, Aapro M. Antiemetic Prophylaxis for Chemotherapy-Induced Nausea and Vomiting N Engl J Med 2016;374:1356-67. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27050207 https://www.nejm.org/doi/pdf/10.1056/NEJMra1515442