drug interaction(s) of digoxin in combination with macrolides
Jump to navigation
Jump to search
Drug interactions
- macrolides (at least erythromycin, clarithromycin) inhibit P-glycoprotein mediated efflux mechanisms of digoxin & increase risk of digoxin toxicity[1][2]
More general terms
References
- ↑ Jump up to: 1.0 1.1 Hines LE, Murphy JE. Potentially harmful drug-drug interactions in the elderly: a review. Am J Geriatr Pharmacother. 2011 Dec;9(6):364-77 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22078863
- ↑ Jump up to: 2.0 2.1 Lee CY, Marcotte F, Giraldeau G, Koren G, Juneau M, Tardif JC. Digoxin toxicity precipitated by clarithromycin use: case presentation and concise review of the literature. Can J Cardiol. 2011 Nov-Dec;27(6):870.e15-6. Epub 2011 Sep 9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21907534