sertraline (Zoloft)

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Introduction

Tradename: Zoloft.

Indications

* may be no better than placebo, serious adverse effects more common than placebo[11]

Contraindications

pregnancy category = c

safety in lactation = ?

Dosage

Tabs: 50 & 100 mg.

Pharmacokinetics

elimination via liver

elimination via kidney

elimination by hemodialysis = -

1/2life = 25-26 hours

Adverse effects

Incidence of SSRI withdrawal syndrome < 0.1%.

Drug interactions

Laboratory

Mechanism of action

More general terms

Additional terms

References

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  2. AHFS 96 Drug Information, GK McEnvoy et al (ed), American Society of Health-System Pharmacists, Bethesda, MD 1998
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  5. 5.0 5.1 Geriatric Dosage Handbook, 6th edition, Selma et al eds, Lexi-Comp, Cleveland, 2001
  6. Prescriber's Letter 9(6):35 2002
  7. 7.0 7.1 Veterans Administration (VA) pharmacy, WLA 2002
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    Jureidini JN, Doecke CJ, Mansfield PR, Haby MM, Menkes DB, Tonkin AL. Efficacy and safety of antidepressants for children and adolescents. BMJ. 2004 Apr 10;328(7444):879-83. Review. No abstract available. Erratum in: BMJ. 2004 May 15;328(7449):1170. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/15073072 <Internet> http://bmj.bmjjournals.com/cgi/content/full/328/7444/879
  12. 12.0 12.1 Pedersen LH et al Selective serotonin reuptake inhibitors in pregnancy and congenital malformations: population based cohort study BMJ 2009;339:b3569 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19776103 <Internet> http://www.bmj.com/cgi/content/full/339/sep23_1/b3569
    Chambers C Selective serotonin reuptake inhibitors and congenital malformations BMJ 2009;339:b3525 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19776102 <Internet> http://www.bmj.com/cgi/content/extract/339/sep23_1/b3525
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  14. 14.0 14.1 Schneider LS, Nelson JC, Clary CM et al An 8-week multicenter, parallel-group, double-blind, placebo- controlled study of sertraline in elderly outpatients with major depression. Am J Psychiatry. 2003 Jul;160(7):1277-85. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12832242
  15. 15.0 15.1 15.2 Reefhuis J et al Specific SSRIs and birth defects: bayesian analysis to interpret new data in the context of previous reports. BMJ 2015;351:h3190 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26156519 <Internet> http://www.bmj.com/content/351/bmj.h3190
  16. Jakubovski E et al. Systematic review and meta-analysis: Dose-response relationship of selective serotonin reuptake inhibitors in major depressive disorder. Am J Psychiatry 2015 Nov 10; <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26552940 <Internet> http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2015.15030331
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    Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
  18. 18.0 18.1 Hedayati SS, Gregg LP, Carmody T et al. Effect of sertraline on depressive symptoms in patients with chronic kidney disease without dialysis dependence: The CAST randomized clinical trial. JAMA. 2017;318(19):1876-1890. Nov 3. https://jamanetwork.com/journals/jama/article-abstract/2661489
    Walther CP, Shah AA, Winkelmayer WC. Treating depression in patients with advanced CKD: Beyond the generalizability frontier. JAMA. 2017;318(19):1873-1874. Nov 3; PMID: https://www.ncbi.nlm.nih.gov/pubmed/29101401 https://jamanetwork.com/journals/jama/article-abstract/2661488
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