Stevens-Johnson syndrome (SJS)

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Etiology

Epidemiology

  • most common in young adults
  • male:female ratio 2:1

Pathology

* histopathology image[6]

Genetics

Clinical manifestations

* images[6][7]

Laboratory

Complications

Differential diagnosis

Management

More general terms

Additional terms

References

  1. H. Quinny Cheng, UCSF Fresno lecture, Oct 21, 1998
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 18. American College of Physicians, Philadelphia 2009, 2012, 2015, 2018.
  3. Carr DR et al Approach to the acute, generalized, blistering patient. Semin Cutan Med Surg. 2007 Sep;26(3):139-46. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18070680
  4. Cotliar J. Approach to the patient with a suspected drug eruption. Semin Cutan Med Surg. 2007 Sep;26(3):147-54. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18070681
  5. Wetter DA, Camilleri MJ. Clinical, etiologic, and histopathologic features of Stevens- Johnson syndrome during an 8-year period at Mayo Clinic. Mayo Clin Proc. 2010 Feb;85(2):131-8 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20118388
  6. 6.0 6.1 6.2 Foster CS, Roy H (images) Medscape: Stevens-Johnson Syndrome http://emedicine.medscape.com/article/1197450-overview
  7. 7.0 7.1 DermNet NZ. (images) Stevens Johnson Syndrome & Toxic Epidermal Necrolysis http://www.dermnetnz.org/reactions/sjs-ten.html
  8. Fein JD, Hamann KL. Images in clinical medicine. Stevens-Johnson syndrome. N Engl J Med 2005 Apr 22; 352:1696 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/15843672 Free full text <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm031127
  9. 9.0 9.1 NEJM Knowledge+ Question of the Week. Nov 8, 2016 http://knowledgeplus.nejm.org/question-of-week/1452/
  10. 10.0 10.1 10.2 Yang MS, Lee JY, Kim J et al Searching for the culprit drugs for Stevens-Johnson syndrome and toxic epidermal necrolysis from a nationwide claim database in Korea. J Allergy Clin Immunol Pract 2020 Feb; 8:690 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31614216 https://www.sciencedirect.com/science/article/abs/pii/S221321981930858X
  11. 11.0 11.1 Heymann E Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis: The Aftermath. AAD Reading Room Content MedPage Today. June 22, 2021 https://www.medpagetoday.com/reading-room/aad/general-dermatology/93214
  12. 12.0 12.1 12.2 12.3 12.4 12.5 Kridin K, Bruggen MC, Chua SL et al Assessment of Treatment Approaches and Outcomes in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Insights From a Pan-European Multicenter Study. JAMA Dermatol. Published online August 25, 2021. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34431984 https://jamanetwork.com/journals/jamadermatology/fullarticle/2783034
  13. 13.0 13.1 Lee EU, Knox C, Phillips EJ Worldwide Prevalence of Antibiotic-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Meta-analysis. JAMA Dermatol. Published online February 15, 2023. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36790777 https://jamanetwork.com/journals/jamadermatology/fullarticle/2801093
  14. 14.0 14.1 NEJM Knowledge+ Dermatology
    Schwartz RA, McDonough PH, Lee BW. Toxic epidermal necrolysis: Part I. Introduction, history, classification, clinical features, systemic manifestations, etiology, and immunopathogenesis. J Am Acad Dermatol. 2013 Aug;69(2):173.e1-13; PMID: https://www.ncbi.nlm.nih.gov/pubmed/23866878 Review.
    Schwartz RA, McDonough PH, Lee BW. Toxic epidermal necrolysis: Part II. Prognosis, sequelae, diagnosis, differential diagnosis, prevention, and treatment. J Am Acad Dermatol. 2013 Aug;69(2):187.e1-16; PMID: https://www.ncbi.nlm.nih.gov/pubmed/23866879 Review.
  15. Noe MH, Micheletti RG. Diagnosis and management of Stevens-Johnson syndrome/toxic epidermal necrolysis. Clin Dermatol. 2020;38:607-12. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33341195
  16. Charlton OA, Harris V, Phan K, et al. Toxic epidermal necrolysis and Steven-Johnson syndrome: A comprehensive review. Adv Wound Care (New Rochelle). 2020;9:426-439. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32520664