sulfasalazine (SSZ, Azulfidine, SAS)

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Introduction

Tradename: Azulfidine.

Indications

Contraindications

Cautions:

Pregnancy category: B

pregnancy category = b

safety in lactation = ?

Dosage

  • mild to moderate inflammatory bowel disease:
    • 500-1000 mg PO QID
    • do not exceed 8 hours between night time & morning dose
  • maintenance 1-2 g/day in divided doses
  • take plenty of water
  • avoid direct sunlight
  • pediatrics: 20-60 mg/kg/day

Tabs: 500 mg.

Liquid: 250 mg/5 mL.

Pharmacokinetics

  • different with different formulations
  • primary site of action is the colon

elimination via kidney

Monitor

Adverse effects

Drug interactions

Mechanism of action

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 356
  3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  5. 5.0 5.1 5.2 5.3 Deprecated Reference
  6. 6.0 6.1 6.2 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
  7. 7.0 7.1 NEJM Knowledge+ Gastroenterology

Database