drug interaction(s) of warfarin with NSAIDs

^[1]^[2]^[3]

Drug interactions

coadministration of warfarin with NSAIDS may increase risk of hematuria, hemotoma & other hemorrhage, especially in elderly on complex drug regimens
NSAIDs in combination with warfarin did not increase risk of bleeding^[3]

↑ Gabb GM. Fatal outcome of interaction between warfarin and a non-steroidal anti-inflammatory drug. Med J Aust. 1996 Jun 3;164(11):700-1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8657040.
↑ Schulman S, Henriksson K. Interaction of ibuprofen and warfarin on primary haemostasis. Br J Rheumatol. 1989 Feb;28(1):46-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2783873
↑ ^3.0 ^3.1 Dalgaard F, Mulder H, Wojdyla DM et al. Patients with atrial fibrillation taking nonsteroidal anti- inflammatory drugs and oral anticoagulants in the ARISTOTLE trial. Circulation 2019 Nov 21 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31747786 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.041296