drug interaction(s) of NSAIDs & aspirin
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Drug interactions
- NSAIDs may inhibit antiplatelet activity of aspirin; interaction has only been reported for ibuprofen[1], but may be general property of NSAIDs; NSAIDs bind to COX-1 in platelets & inhibit platelet aggregation; however, binding is reversible & it competitively inhibits binding of aspirin to COX-1; aspirin binds irreversibly to COX-1 in platelets, permanently eliminating their tendency to aggregrate