mesalamine (Asacol, Rowasa, Pentasa, Pentasacaps, Lialda, Apriso, Canasa, Delzicol)

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Introduction

Tradenames: Asacol, Rowasa, Pentasa, Apriso.

Indications

* activity minimal in Crohn's disease[8]

Contraindications

pregnancy-category B

safety in lactation ?

Dosage

Tabs: 250 mg (Pentasa) & 400 mg (Anascol). Tab (delayed time release): 400 mg. Lialda 1.2 g MMX Multi-Matrix System QD dosing[6]

Suppository: 500 mg. Enema: 4 g/60 mL.

Pharmacokinetics

Adverse effects

Mechanism of action

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 356
  3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  5. 5.0 5.1 Prescriber's Letter 14(3): 2007 Drug Therapy for Ulcerative Colitis Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=230308&pb=PRL (subscription needed) http://www.prescribersletter.com
  6. 6.0 6.1 Kamm MA et al, Once daily, high concentration MMX mesalamine in active ulcerative colitis. Gastroenterology 2007, 132:66 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17241860
  7. 7.0 7.1 Deprecated Reference
  8. 8.0 8.1 8.2 8.3 8.4 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015

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