topical glucocorticoid (topical steroid)

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Introduction

Agents applied to skin. Excludes nasal & inhaled glucocorticoids

Classification

* classification from most to least potent

Contraindications

Adverse effects

* adverse effects more common when applied to areas of occlusion by clothing or skin folds[2]; use least potent topical glucocorticoid when appled to these areas[7]

Drug interactions

Mechanism of action

Notes

More general terms

More specific terms

References

  1. Prescriber's Letter 16(12): 2009 Comparison of Topical Corticosteroids Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=251227&pb=PRL (subscription needed) http://www.prescribersletter.com
  2. Jump up to: 2.0 2.1 2.2 2.3 2.4 2.5 Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 18. 19. American College of Physicians, Philadelphia 2009, 2012, 2015, 2018, 2022.
  3. Prescriber's Letter 18(10): 2011 Hyperglycemia Associated with Non-oral and Locally Injected Corticosteroids Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=271022&pb=PRL (subscription needed) http://www.prescribersletter.com
  4. Jump up to: 4.0 4.1 4.2 Chi CC et al Pregnancy Outcomes After Maternal Exposure to Topical Corticosteroids. A UK Population-Based Cohort Study. JAMA Dermatol. Published online September 04, 2013 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24005903 <Internet> http://archderm.jamanetwork.com/article.aspx?articleid=1735120
  5. Del Rosso J, Friedlander SF. Corticosteroids: options in the era of steroid-sparing therapy. J Am Acad Dermatol. 2005 Jul;53(1 Suppl 1):S50-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15968264
  6. Jump up to: 6.0 6.1 Hengge UR, Ruzicka T, Schwartz RA, Cork MJ. Adverse effects of topical glucocorticosteroids. J Am Acad Dermatol. 2006 Jan;54(1):1-15 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16384751
  7. Jump up to: 7.0 7.1 7.2 Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
    Geriatric Review Syllabus, 9th edition (GRS9) Medinal-Walpole A, Pacala JT, Porter JF (eds) American Geriatrics Society, 2016
  8. Jump up to: 8.0 8.1 Haeck IM, Rouwen TJ, Timmer-de Mik L Topical corticosteroids in atopic dermatitis and the risk of glaucoma and cataracts. J Am Acad Dermatol. 2011 Feb;64(2):275-81 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21122943
  9. Jump up to: 9.0 9.1 Skojec A, Foulke G, Kirby JS. Variation in the Cost of Generic Topical Corticosteroids. JAMA Dermatol. 2015 Aug 19 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26288382
  10. Beer K, Downie J. Sequelae from inadvertent long-term use of potent topical steroids. J Drugs Dermatol. 2007 May;6(5):550-1 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17679193
  11. Jump up to: 11.0 11.1 Song H, Adamson A, Mostaghimi A. Medicare Part D payments for topical steroids: Rising costs and potential savings. JAMA Dermatol 2017 Aug; 153:755. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28453645 <Internet> http://jamanetwork.com/journals/jamadermatology/article-abstract/2623534
  12. Jump up to: 12.0 12.1 Andersen YMF, Egeberg A, Ban L et al. Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts. Diabetes Care 2019 Jun; 42:1095 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/30936111 <Internet> http://care.diabetesjournals.org/content/42/6/1095
  13. Ference JD, Last AR Choosing topical corticosteroids. Am Fam Physician. 2009 Jan 15;79(2):135-40. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19178066 Free article.
  14. Jump up to: 14.0 14.1 Egeberg A, Schwarz P, Harslof T et al Association of Potent and Very Potent Topical Corticosteroids and the Risk of Osteoporosis and Major Osteoporotic Fractures. JAMA Dermatol. Published online January 20, 2021. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33471030 https://jamanetwork.com/journals/jamadermatology/article-abstract/2775153
    Jackson RD Topical Corticosteroids and Glucocorticoid-Induced Osteoporosis - Cumulative Dose and Duration Matter. JAMA Dermatol. Published online January 20, 2021 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33471024 https://jamanetwork.com/journals/jamadermatology/article-abstract/2775150