Flurandrenolide Topical (Cordran)

Indications

• relief of inflammatory dermatoses (dermatitis)
  • allergic dermatitis
    • atopic dermatitis, contact dermatitis
  • seborrheic dermatitis
  • dandruff
  • discoid lupus
  • granuloma annulare
  • psoriasis
  • pruritus, anal pruritus
  • lichen simplex chronicus
• alleriges
• cutaneous T-cell lymphoma

Dosage

• apply BID/TID

cream/ointment 0.025% & 0.05% (30g, 60g).

Medium potency (0.025%).

Adverse effects

• uncommon (< 1%)
  • burning, itching, irritation, dryness, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin atrophy,, striae, miliaria, intracranial hypertension, maceration of skin, suppression of hypothalamic-pituitary-adrenal axis, Cushing's syndrome, growth retardation, secondary infection

• drug adverse effects of glucocorticoids
• drug adverse effects of topical glucocorticoids
• drug adverse effects of immunosuppressive agents

Mechanism of action

• anti-inflammatory; topical glucocorticoid class 4, class 5

More general terms

• flurandrenolide
• topical glucocorticoid (topical steroid)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=15209
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3392
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=657340