cutaneous T-cell lymphoma (CTCL)
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Etiology
Clinical manifestations
- crusted skin lesions developing over a period of 2 months (case report[1] of lesions appearing on nose)
- occasional bloody discharge
- no pain
- no constitutional or other systemic symptoms[1]
- ataxia with CNS metastases (case report)[1]
Laboratory
- skin biopsy
- bone marrow biopsy (no involvement, case report)[1]
Radiology
- computed tomography
- no lymphadenopathy or metastases (case report)[1]
Complications
- CNS metastases may include pons, cerebellum (case report)[1]
- lung metastases, pleuro-pulmonary nodules (case report)[1]
- cognitive impairment[4]
Management
- topical glucocorticoids +/- acitretin, psoralen & UV light & IFN-alfa for early stage disease[2]
- chemotherapy* with autologous stem-cell transplantation for metastatic disease (case report)[1]
- gentian violet promote apoptosis & inhibit proliferation of cutaneous T-cell lymphoma cells in vitro[3]
- suggested as inexpensive, topical therapy[3]
* purine analog, histone deacetylase inhibitor, monoclonal Ab
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References
- ↑ Jump up to: 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Aljishi M, Barrow C Cutaneous T-Cell Lymphoma N Engl J Med 2015; 372:2437. June 18, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26083208 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm1406401
- ↑ Jump up to: 2.0 2.1 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
- ↑ Jump up to: 3.0 3.1 3.2 Wu J, Wood GS. Analysis of the Effect of Gentian Violet on Apoptosis and Proliferation in Cutaneous T-Cell Lymphoma in an In Vitro Study. JAMA Dermatol. Published online August 29, 2018. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30167641 https://jamanetwork.com/journals/jamadermatology/fullarticle/2697566
- ↑ Jump up to: 4.0 4.1 Garlewicz J Cutaneous T-Cell Lymphoma and Psoriasis Associated With Memory Impairment. The Dermatologist. Aug 8, 2022 https://www.hmpgloballearningnetwork.com/site/thederm/news/cutaneous-t-cell-lymphoma-and-psoriasis-associated-memory-impairment
Damiani G, Tacastacas JD, Wuerz T et al. Cognition/psychological burden and resilience in cutaneous T-cell lymphoma and psoriasis patients: real-life data and implications for the treatment. Biomed Res Int. Published online July 21, 2022 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35937394 PMCID: PMC9348939 Free PMC article